For the tenth time, the Charles Rodolphe Brupbacher Prize will be awarded in conjunction with an international symposium. The price of 100,000 Swiss francs for each researcher, is one of the most prestigious in the world of research. The prize is awarded every two years for investigators who have made outstanding contributions to oncology. The conference will also honor five young researchers who will receive a prize for young researcherThe nearly 150 multiple organ donors each year in Sweden 50-60 lung transplants allow to run. Gained from research funds, the Sahlgrenska University Hospital machine is an excellent tool to provide more lung transplants, believes Dellgren.
Bert Vogelstein is among the most cited scientists in the field of biomedicine. He is best known for his innovative work on the genesis of colon cancer. Tumors of the large intestine are particularly suitable for analysis, as progress from a benign to a malignant tumor can be clinically observed by colonoscopy.
Hoeijmakers identified and characterized several genes involved in the repair process. It ?been shown that some forms of DNA repair capacity may cause limited the exact opposite of a tumor, or premature aging.
Sequential accumulation of mutations results Vogelstein and tumor growth have been distributed widely recognized and form the basis for the prevention, early diagnosis and treatment of colorectal cancers. Vogelstein has recently started to analyze the genome against cancer, which is the sum of all the genes in a cell. Understanding the genetic makeup of a tumor forms the basis for personalized treatment of cancer, an important goal in clinical oncology.
A complex system of DNA repair ensures the stability of our genome. Hoeijmakers Jan has gained international recognition for having identified the main aspects of the molecular basis of DNA repair and its role in the development of both cancer and premature aging.
Vogelstein said that the first, smaller accumulations of abnormal cells are caused by a mutation in the APC gene, a tumor suppressor gene that controls cell division. The mutation of the APC gene is also responsible for the inherited familial adenomatous polyposis, a disease characterized by a large number of polyps in the bowel wall. If not removed, these polyps can become.
Other mutations activate genes that encode growth factors . All these DNA mutations mediate a slow but steady growth from small, then more, then the benign polyps that progress to cancer.
Even if it takes an average of 17 years for a small polyp to develop into cancer, then the process is accelerated, resulting generally in two years for a highly malignant cancer that is metastatic to regional lymph nodes and organs away.
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